below this kind of problems, noticed substitutions concerning genomes approximate a random sample on the mutations which have transpired. for that reason, when range is relaxed, biases within the styles of substitutions https://u26022548.ct.sendgrid.net/ls/click?upn=u001.7K-2B9oOnOGnyYykTMBcTno3rhP2N5uz9Lp8eSx0e7IlVZUL-2F68DjCED2F1T91kKDmGiOS6U3xZCbPcZ5dJhWbNHBxR3vy0imM1YybrBIrycY-3DNBnO_u2xhDZukFl1p2ai3jPaySW3cMOABo0xOBk-2B-2B1y3zdDO0XLGKnFT8C8sDWqCCJOxvhx4-2FRR9TvoQUSnbD5hqt-2FfZcl0vMzt5a0q5E3pgh-2BKUDysyawhYXOamBeDdUTh9MA5Rkqh2FD9mBnRrnnZARQe3uvYH8cGg4UaZjMzAfwFfZBsQm5Uy4g6Me1vH5zpjsSYiNDSfFV9VTjx-2B9Hw5skmEyTeZP2sj62OMGoCpo8UMpQ7qO38qmnRTMQPhlWBK1fs7EkvuESSTJDJgvAF7n3DRiQjX7uE09DSxOkaGDBzg-3D