Abstract Background Manual annotation of enzymatic functions cannot keep up with automatic genome sequencing. In this work we explore the capacity of InterPro sequence signatures to automatically predict enzymatic function. Results We present EnzML. a multi-label classification method that can efficiently account also for proteins with multiple enzymatic functions: 50. https://www.roneverhart.com/5-5-Parlor-Palm-Artificial-Tree-in-White-Tower-Planter/