ABSTRACT Of the approximately 10 million cases of Mycobacterium tuberculosis (Mtb) infections each year. over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is predominantly caused by mutations that decrease the activity of the bacterial enzyme KatG. which mediates the conversion of the pro-drug INH to its active form INH-NAD. https://www.kingarte.com/product-category/accessoriesmixer-parts/